Dead Man's unconventional story focuses on William Blake (Johnny Depp in a wonderfully restrained performance), an accountant traveling West from Cleveland, Ohio in response to a promised position at the Dickinson Metal Works in the industrial township of Machine. During his seemingly interminable train journey - which is financed from the money he has received from the death of his parents - Blake is confronted by the train's manic stoker (Crispin Glover), who warns the accountant that only death awaits him. In a curious monologue, the stoker suggests that Blake's fate is pre-destined. Blake soon arrives at his destination - the stagnant and post-apocalyptic frontier town of Machine. To the young arrival, it is a decadent, lawless community, devoid of human compassion and steeped in cold-blooded ruthlessness. Hand-made coffins line the mortician's emporium; sun-bleached buffalo skulls are featured on display in another store; tethered horses urinate in the street; and a young prostitute is forced to fellate a man at gunpoint. Upon entering the office of the Dickinson Metal Works, Blake presents his job application to John Scholfield (John Hurt), the firm's administrative officer, who promptly informs Blake that his position has been filled by another accountant. Ignoring Blake's futile attempts at reason, Scholfield taunts him, suggesting that if he truly desires the position, then he should take his complaint to John Dickinson (Robert Mitchum in his last screen role), the Metal Work's proprietor. However, Dickinson's response to Blake's circumstance is uncharitable, to say the least; Blake is forced out of the manager's office at gunpoint. Penniless and desperate, Blake wanders about Machine well into the night where he meets Thel Russel (Mili Avital), a prostitute, who feels sympathy for the dejected newcomer. However, fate intervenes with the appearance of Charles ‘Charlie' Ludlow Dickinson (Gabriel Byrne), the son of John Dickinson; due to a tragic misunderstanding, Blake is involved in a gunfight which results in Charlie's death. Seething with vengeful rage, Dickinson assembles a trio of the frontier's finest killers - Cole Wilson (Lance Henriksen), a pathological cannibal; Conway Twill (Michael Wincott), a skilled bounty hunter who talks incessantly and sleeps with a teddy bear; and Johnny “The Kid” Pickett (Eugene Byrd), a fourteen-year old Negro boy and cold-blooded sociopath - to apprehend Blake, dead or alive. Falsely accused as a cowardly murderer and relentlessly pursued, Blake journeys deeper in the unforgiving badlands on a personal and spiritual odyssey that will radically transform him. Weary and half- starved, he soon finds an uneasy alliance with Nobody (Gary Farmer), an native American Indian, who believes that Blake is actually the reincarnation of his namesake - the late English inventor and poet, William Blake.
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